What is (3,3-Dimethyl)butyldimethylsilyl chloride

(3,3-Dimethyl)butyldimethylsilyl chloride , or TBSCl, is a silane compound with the formula Me2SiCl. Because of its silane nature, it is a reactive chloride. This article will discuss a variety of applications of TBSCl. If you’re looking for a chemical compound, try these methods to determine its toxicity.


Podophyllotoxin dimeric derivatives are chemically similar to monomeric compounds but display differing anticancer activity. Dimerization might not be a good strategy to enhance the potency of this anticancer agent. The present study presents the synthesis and characterization of a dimeric derivative of podophyllotoxin.

A series of novel 4b-sulfonylurea derivatives of podophyllotoxin were synthesized and evaluated in vitro against four cancer cell lines. Out of the four derivatives, compounds 14c and 14e showed the highest cytotoxicity and were selected as lead molecules for further development. Moreover, 4b-1,2,3-triazole derivatives were found to have better anticancer activity and higher binding affinity to topoisomerase-II. However, the role of dimerization in enhancing anticancer activity is still unclear.

Various reagents have been used in the synthesis of podophyllotoxin. For instance, tert-butyldimethylsilyl chloride, imidazole, and CHCl 3 were combined to form picropodophyllin-TBDMS. The latter was purified by silica gel column chromatography.

Podophyllotoxin compounds may differ due to their linking spacers. Compound 29 contains perbutyrylated glucose residue. Its potency is significantly higher compared to the others. In addition, this compound has a higher activity than the others, which are compounds 25, 27, and 28. These differences in potency can be attributed to the linking spacers in podophyllotoxin compounds.

Podophyllotoxin silylated with tert-butyldimethylsilyl chloride

Podophyllotoxin is the prototypical aryltetralin lignan natural product like CAS:172684-43-4. Several steps in its synthesis are required to achieve this desired structure, including a Pd-catalyzed C(sp3)-H arylation and a conformational biasing element. In this paper, we present a synthetic method that involves the use of commercial bromopiperonal as the starting material and the five steps described in this manuscript.

In this process, 275 mg (9 mmol) of tertiary amine 11a/11c is dissolved in 1.5 mL of dioxane, followed by the addition of H2O and sodium hydrochloride. After refluxing for 20 h, the solvent is evaporated to dryness, and the residue is used for the deprotection step without further purification.

Similarly, the t-butyldimethylsilafuran byproduct is formed as a result of the 2-hydroxymethylphenylsilane system. The 2-hydroxypropyl analog, however, only results in benzaldehyde and aryl chloride. This specialty ligand is also used in nickel-catalyzed cross-coupling reactions.

Unlike polyphenyldimethylsilylsilanes, tert-butyldi-methylsilylsilyl chloride is a versatile antimicrobial agent. The compounds can be stored in solutions without fluoride promotion, which has several advantages. The compounds are highly soluble in organic solvents and can be stored without any need to undergo fluoride promotion.

During the synthesis of this tetrahydrohyldimethylsilyl chlorides, monensin is synthesized from natural products. In addition, tert-butyldimethylsilyl chloride is a nucleophilic reagent that allows for the formation of 2,3-disubstituted indoles.

After synthesizing the jacaranone derivatives, the compounds were evaluated for their antiprotozoal and antiproliferative activities. Antiprotozoal activity was assessed against Plasmodium falciparum NF54 and Trypanosoma brucei rhodesiense STIB900. A selectivity index was also calculated based on cytotoxicity against L6 cells.

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